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THIS STEM-CELL IMPLANT MIGHT HALT BLINDNESS

Date: 2018-04-09



09 april 9am

 

An eye implant, which is made up of a thin sheet of human embryonic stem cells, might be an effective treatment for a common form of vision loss.

Researchers at the University of Southern California grew stem-cell membranes in a sterile lab for a month and then inserted them into the eyes of four people with "dry" macular degeneration, which is the leading cause of blindness in developed countries. An estimated 196 million people worldwide will have some form of macular degeneration by 2020.

People with this type of 'blindness' suffer from a progressive thinning of the retinal pigment epithelium, a layer of cells that support and nourish the light-sensing photoreceptors. Without this vital layer, which the implant is intended to replace, the photoreceptor cells also die off, and people slowly lose their eyesight.

The researchers monitored four patients over the course of a year and found that their eyesight didn't decline. The study was meant to test the safety of the implant, so only patients with very advanced macular degeneration were included. Due to that, the author Amri Kashani says, he did not expect to see any improvement in vision. "But after surgery, one patient could read 17 more letters on an eye chart than before surgery," he added.

Two of the patients were able to focus their glaze better than before. Kashani thinks the implants will be more effective for people in earlier stages of the disease.

When stem cells were first extracted from human embryos 20-years-ago, scientists marvelled at their ability to change into any type of cell in the body and through the cells would soon be used to treat all types of diseases. The dream has yet to be realised; there are no embryonic stem-cell treatments approved by the US Food and Drug Administration, and most human studies of such therapies have show unremarkable results.

The researchers have, for example, tried injecting embryonic stem cells directly into the eye, but the cells moved around in the eye and weren't very effective. "The reason we’re encouraged is that we’re replacing the exact anatomical defect that is causing the disease," Kashani says.

Another research team, at the Moorfields Eye Hospital in London, recently reported that a similar stem-cell patch they developed was able to restore sight in two patients with the wet form of macular degeneration, which is caused by abnormal blood vessels that leak into the central part of the retina.

However, both these studies were small and neither had control groups, so it is hard to know whether the perceived benefits can actually be credited to the stem-cell therapies.

Paul Knoepfler, who is a stem-cell biologist at the University of California, says the work on the stem-cell therapies has been slow due to the tremendous safety risks involved. "We’ve seen what can go horribly wrong with shortcuts with stem cells by for-profit clinics," says Knoepfler.

Last year, the FDA vowed to crack down on spurious clinics that blinded patients with eye injections of stem cells derived from people's fat.

Keep an eye out for any updates to come.



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